Is IL12 necessary in experimental hypersensitivity pneumonitis?
نویسندگان
چکیده
منابع مشابه
Interferon-gamma is necessary for the expression of hypersensitivity pneumonitis.
Farmers lung disease is a common form of hypersensitivity pneumonitis (HP) and is characterized by inflammation and granuloma formation in the lung. Interferon-gamma is important for the expression of granulomatous diseases caused by infectious agents; however, the role this mediator in regulating expression of the granulomatous response to inhaled antigen is not known. To evaluate this, we com...
متن کاملIs Necessary for the Expression of Hypersensitivity Pneumonitis
Farmers lung disease is a common form of hypersensitivity pneumonitis (HP) and is characterized by inflammation and granuloma formation in the lung. Interferong is important for the expression of granulomatous diseases caused by infectious agents; however, the role this mediator in regulating expression of the granulomatous response to inhaled antigen is not known. To evaluate this, we compared...
متن کاملGenetic control of experimental murine hypersensitivity pneumonitis.
lenged with PDE developed extensive interstitial infiltrations of macrophages and multinucleated giant cells that were most prominent around respiratory bronchioles but also extended into the alveolar septa. There were also associated perivascular lymphocytic and plasma cell infiltrates. Neither immunization nor aerosol challenge per se resulted in pulmonary inflammation. In contrast, C57BL/10 ...
متن کاملHypersensitivity pneumonitis
PURPOSE OF REVIEW To bring readers up to date on recent reports, both clinical and basic understanding, on hypersensitivity pneumonitis. RECENT FINDINGS Although many antigens and environmental settings have already been described as sources of this hyperimmune pulmonary disease, the literature continues to bring forth other conditions that can cause hypersensitivity pneumonitis. We also high...
متن کاملHypersensitivity pneumonitis.
Clinical manifestations of hypersensitivity pneumonitis may closely mimic other interstitial lung diseases, and the disease onset is usually insidious. High-resolution computed tomography and bronchoalveolar lavage are the sensitive and characteristic diagnostic tests for hypersensitivity pneumonitis. The relevant antigen to hypersensitivity pneumonitis cannot be identified in up to 20% to 30% ...
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2002
ISSN: 0959-9673
DOI: 10.1046/j.1365-2613.2002.00217.x